Dr Zaza Ndhlovu works on cellular immune responses to HIV-1, with the ultimate goal of finding a phenotypic target for an HIV vaccine. His research programme includes studies geared towards understanding initial events that contribute to immune dysfunction and subsequent disease progression. He uses excisional lymph node samples from acute and chronic HIV infected patients to interrogate how brief exposure to HIV influences induction and durability of protective immune responses.
Zaza received his PhD in Molecular Microbiology and Immunology from Johns Hopkins University, and did his postdoctoral training at Harvard University. During this time, he studied CD8+ T cell responses in a special group of individuals capable of spontaneous HIV suppression in the absence of antiretroviral therapy – called ‘elite controllers’. He made significant discoveries about key features of HIV-specific CD8+ T cell subsets that are able to inhibit viral replication and drive immune escape in elite controllers.
After securing a Faculty position at Harvard University, he decided to relocate his research program to South Africa. “I reasoned that incidence rates of close to 10% per year in KwaZulu-Natal would enable me to address unique aspects of the host immune response to HIV that could not be undertaken where I had trained, while at the same time I could contribute to scientific capacity building needed to meet current and future African medical challenges,” Zaza said. The move brought him to the epicenter of the HIV epidemic and has allowed him access to well pedigreed acute infection samples.
Zaza’s academic appointments include member of Faculty at AHRI, Instructor in Medicine at Harvard Medical School, Assistant in Immunology at Massachusetts General Hospital and Adjunct Faculty at University of KwaZulu-Natal. He is also an HHMI International Research Scholar.
Get in touch with Zaza via firstname.lastname@example.org
Click here for a full list of publications.
The Ndhlovu Group focuses on understanding how immune regulation in the lymph node microenvironment affects HIV-1 persistence in ART treated aviremic patients, with the goal of gaining new insights that can inform novel HIV cure strategies.
Meet the Team
Bongiwe Mahlobo received her Master’s from the University of Pretoria. Her primary research focused on the in silico functional characterization of hypothetical proteins. Bongiwe's PhD in HIV immunology is focused on understanding the role of follicular CD4+ T cells in lymphoid tissues of early treated HIV-1 infected individuals.
Funsho Ogunshola got his master’s degree in Health Sciences from UKZN. His project investigated why closely related HLA alleles restricting identical HIV epitopes are often associated with differential clinical outcomes. His PhD work is focused on investigating transcription and epigenetic regulation of CD8 T cells in lymphoid tissues and peripheral blood in the context of HIV infection.
Thandeka Nkosi obtained her Master’s degree in Medical Sciences from UKZN. Her project showed that very early antiretroviral (ART) initiation is associated with a mitigated but measurable CD8 T cell response that is functionally competent and durable. She also previously worked as a research assistant at the HIV Pathogenesis Programme. Thandeka’s main responsibilities at AHRI include overseeing the day-to-day running of the Ndhlovu lab, conducting lab bench work, training new students and staff, and lab inventory management.
Selected Recent Publications
Laher, F., Ranasinghe, S., Porichis, F., Mewalal, N., Pretorius, K., Ismail, N., … Ndhlovu, Z. M. (2017).. HIV Controllers Exhibit Enhanced Frequencies of Major Histocompatibility Complex Class II Tetramer(+) Gag-Specific CD4(+) T Cells in Chronic Clade C HIV-1 Infection.. Journal of Virology, 91(7), e02477-16.
Ndhlovu, Z., Kamya, P., Mewalal, N., Kløverpris, H. N., Nkosi, T., Pretorius, K., … Walker, B. D. (2015). Magnitude and kinetics of CD8+ T cell activation during hyperacute HIV infection impacts viral set point. Immunity, 43(3), 591–604.
Ndhlovu, Z. M., Chibnik, L. B., Proudfoot, J., Vine, S., McMullen, A., Cesa, K., … Kaufmann, D. E. (2013) . High-dimensional immunomonitoring models of HIV-1–specific CD8 T-cell responses accurately identify subjects achieving spontaneous viral control. . Blood, 121(5), 801–811. .
Chen, H., Ndhlovu, Z. M., Liu, D., Porter, L. C., Fang, J. W., Darko, S., … Walker, B. D. (2012). T cell receptor clonotypes modulate the protective effect of HLA class I alleles in HIV-1 infection.. Nature Immunology, 13(7), 691–700. .
Ndhlovu, Z. M., Oelke, M., Schneck, J. P., & Griffin, D. E. (2010). Dynamic regulation of functionally distinct virus-specific T cells. . Proceedings of the National Academy of Sciences of the United States of America, 107(8), 3669–3674..