Mark Siedner

Mark Siedner

Dr. Mark Siedner is an infectious diseases specialist and clinical epidemiologist. His clinical and research work is focussed on decreasing the burden of infectious diseases on health and quality of life. Mark also has a passion for transferring these skills to trainees on both sides of the Atlantic Ocean. He is a member of AHRI Faculty, and also holds the positions of Associate Professor of Medicine at Harvard Medical School, Assistant Physician at Massachusetts General Hospital and Visiting Associate Professor of Medicine at Mbarara University of Science and Technology.

In addition, Mark serves as the primary mentor to dozens of medical students, medical trainees and junior faculty, and said he was humbled and delighted to be awarded a Harvard Medical School Young Mentor Award in recognition for these activities. He continues to dedicate significant time to didactics, both as a teaching clinician on the medical wards, but also through formal leadership on research capacity building. Much of this work has been for trainees in Uganda, where he teaches courses on epidemiology, biostatistics, manuscript and grant writing. He was honoured for this service with a Visiting Associate Professor of Medicine title at the Mbarara University of Science and Technology, where he is also a senior mentor on the NIH-funded D43 Mentored Research Training Grant on capacity building in HIV and chronic disease.

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The Siedner Group

Dr. Siedner’s group research programme lies in the intersection between population health and clinical research, and is aimed at combatting the causes of morbidity and mortality among people living with HIV in low-income countries.

His active research projects include:

  1. Evaluating interventions to address barriers to HIV care, including transportation costs and poor communication systems
  2. Directing a longitudinal study of older HIV-infected persons and HIV-uninfected comparators to understand how HIV contributes to chronic diseases and aging
  3. Leading a randomised clinical trial to measure the efficacy and cost-effectiveness of HIV resistance testing to improve management of virologic failure in sub-Saharan Africa. This work has led to over 90 peer-reviewed publications and spurred HIV practice changes in Uganda, such as streamlining treatment initiation and incorporation of health interventions into clinical care.

Mark’s overarching goals at AHRI are to help strengthen the clinical research programme through study of the intersection between infectious and non-communicable diseases in rural South Africa, and to promote innovative, cross-disciplinary research between AHRI’s population and basic science programmes.

Selected Recent Publications

Siedner, M. J., Bwana, M. B., Moosa, M.-Y. S., Paul, M., Pillay, S., McCluskey, S., … Marconi, V. C. (2017). The REVAMP trial to evaluate HIV resistance testing in sub-Saharan Africa: a case study in clinical trial design in resource limited settings to optimize effectiveness and cost effectiveness estimates. HIV Clinical Trials, 18(4), 149–155.

Siedner, M. J., Kim, J.-H., Nakku, R. S., Bibangambah, P., Hemphill, L., Triant, V. A., … Hunt, P. W. (2016). Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy.  Journal of Infectious Diseases, 213(3), 370–378.

Siedner, M. J., Kim, J.-H., Nakku, R. S., Hemphill, L., Triant, V. A., Haberer, J. E., … Bangsberg, D. R. (2016). HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS, 30(4), 667–670.

Siedner, M. J., Santorino, D., Lankowski, A. J., Kanyesigye, M., Bwana, M. B., Haberer, J. E., & Bangsberg, D. R. (2015). A combination SMS and transportation reimbursement intervention to improve HIV care following abnormal CD4 test results in rural Uganda: a prospective observational cohort study. BMC Medicine, 13(1).