Dr Henrik Kløverpris’ interest in HIV immunology first piqued at MSc level when, in 2005, he coordinated an HIV T-cell vaccine trial in Anders Fomsgaard’s lab at the Statens Serum Institute in Copenhagen, Denmark. In 2008 Henrik joined Philip Goulder’s lab at the University of Oxford to study the impact of T-cell responses in control of HIV infection at the population level. Naturally, his PhD and postdoc work there led to several visits to South Africa – the epicentre of the global HIV epidemic. When Henrik was awarded a research prize from the Danish Research Council in 2012, he used that opportunity to join the KwaZulu-Natal Research Institute for TB-HIV in Durban – a place that had left an indelible mark on him. Henrik’s research was based in the lab of Dr Alasdair Leslie – a former colleague from the University of Oxford. At AHRI, Henrik has worked to develop a new area of HIV research. He was recently awarded a prestigious Sir Henry Dale Wellcome Trust Fellowship, through University College London, to start his own research group as an AHRI Junior Faculty member. Henrik’s work focuses on innate lymphoid cells and mucosal barrier sites in HIV infection using human tissue samples from local hospitals in and around Durban.
Click here for a full list of publications.
The Kløverpris research group focusses on innate lymphoid cells and mucosal barrier sites in HIV infection, using human tissue samples from local hospitals in and around Durban.
Meet the Team
Alveera Singh has a Master’s degree in Biotechnology and a PhD in Applied Science from the Durban University of Technology. She joined K-RITH in 2015 to work on HIV infection and immunology as a research technician. Alveera currently holds a SANTHE Postdoctoral Fellowship at AHRI. Her research focusses on Innate Lymphoid Cells (ILCs) during HIV infection.
Rabiah Fardoos completed her BSc degree in Pharmacy at the University of Copenhagen. Her Master’s project, supervised by Dr Henrik Kløverpris, involves single-cell profiling of tissue with resident and circulating HIV specific CD8+ T cells.
Selected Recent Publications
Kloverpris, H. N., Kazer, S. W., Mjosberg, J., Mabuka, J. M., Wellmann, A., Ndhlovu, Z., Yadon, M. C., Nhamoyebonde, S., Muenchhoff, M., Simoni, Y., Andersson, F., Kuhn, W., Garrett, N., Burgers, W. A., Kamya, P., Pretorius, K., Dong, K., Moodley, A., Newell, E. W., Kasprowicz, V., Abdool Karim, S. S., Goulder, P., Shalek, A. K., Walker, B. D., Ndung'u, T., & Leslie, A. (2016). Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity, 44(2), 391-405. doi: 10.1093/infdis/jiw093.
Kloverpris, H. N., Leslie, A., & Goulder, P. (2015). Role of HLA Adaptation in HIV Evolution. Front Immunol, 6, 665. doi: 10.3389/fimmu.2015.00665.
Simoni, Y., Fehlings, M., Kloverpris, H. N., McGovern, N., Koo, S. L., Loh, C. Y., Lim, S., Kurioka, A., Fergusson, J. R., Tang, C. L., Kam, M. H., Dennis, K., Lim, T. K., Fui, A. C., Hoong, C. W., Chan, J. K., Curotto de Lafaille, M., Narayanan, S., Baig, S., Shabeer, M., Toh, S. E., Tan, H. K., Anicete, R., Tan, E. H., Takano, A., Klenerman, P., Leslie, A., Tan, D. S., Tan, I. B., Ginhoux, F., & Newell, E. W. (2016). Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency. Immunity. doi: 10.1016/j.immuni.2016.11.005.
Kloverpris, H. N., McGregor, R., McLaren, J. E., Ladell, K., Harndahl, M., Stryhn, A., Carlson, J. M., Koofhethile, C., Gerritsen, B., Kesmir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., & Buus, S. (2015). CD8+ TCR Bias and Immunodominance in HIV-1 Infection. 194(11), 5329-5345. doi: 10.4049/jimmunol.1400854.
Kloverpris, H. N., Cole, D. K., Fuller, A., Carlson, J., Beck, K., Schauenburg, A. J., Rizkallah, P. J., Buus, S., Sewell, A. K., & Goulder, P. (2015). A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology, 12, 20. doi: 10.1186/s12977-015-0149-5.