Dr Henrik Kløverpris’ interest in HIV immunology first piqued at MSc level when, in 2005, he coordinated an HIV T-cell vaccine trial in Anders Fomsgaard’s lab at the Statens Serum Institute in Copenhagen, Denmark. In 2008 Henrik joined Philip Goulder’s lab at the University of Oxford to study the impact of T-cell responses in control of HIV infection at the population level. Naturally, his PhD and postdoc work there led to several visits to South Africa – the epicentre of the global HIV epidemic. When Henrik was awarded a research prize from the Danish Research Council in 2012, he used that opportunity to join the KwaZulu-Natal Research Institute for TB-HIV in Durban – a place that had left an indelible mark on him. Henrik’s research was based in the lab of Dr Alasdair Leslie – a former colleague from the University of Oxford. At AHRI, Henrik has worked to develop a new area of HIV research. He was recently awarded a prestigious Sir Henry Dale Wellcome Trust Fellowship, through University College London, to start his own research group as an AHRI Junior Faculty member. Henrik’s work focuses on innate lymphoid cells and mucosal barrier sites in HIV infection using human tissue samples from local hospitals in and around Durban.
Get in touch with Henrik via email@example.com
The Kløverpris research group focusses on innate lymphoid cells and mucosal barrier sites in HIV infection, using human tissue samples from local hospitals in and around Durban.
Meet the Team
Alveera Singh has a Master’s degree in Biotechnology and a PhD in Applied Science from the Durban University of Technology. She joined K-RITH in 2015 to work on HIV infection and immunology as a research technician. Alveera currently holds a SANTHE Postdoctoral Fellowship at AHRI. Her research focusses on Innate Lymphoid Cells (ILCs) during HIV infection.
Osaretin Emmanuel Asowata
Emmanuel was awarded a PhD in Medical Microbiology from the University of KwaZulu-Natal. His PhD work focused on factors influencing the effectiveness of a monovalent rotavirus vaccine in South Africa. Emmanuel joined AHRI as a postdoctoral research fellow in 2018 where he will focus on innate immune lymphoid cells (ILCs) in the gut to explore their role in homeostasis and HIV gut pathology.
Yenzekile Zungu was awarded her Honours in Medical Microbiology at the University of KwaZulu-Natal. Her Master’s work focuses mainly on characterising the function of innate lymphoid cells within HIV infected mucosal tissue.
Rabiah Fardoos completed her BSc degree in Pharmacy at the University of Copenhagen. Her Master’s project focused on implementing single cell platforms at AHRI to study tissue resident and circulating HIV specific CD8+ T cells in human tonsils. Her PhD studies, supervised by Dr Henrik Kløverpris, use high throughput single cell RNAseq data sets from HIV infected tissue to study immune cells involved in tissue homeostasis and effector function at tissue locations.
Selected Recent Publications
Ardain, A., Domingo-Gonzalez, R., Das, S. ... , Kløverpris, H., Colonna, M., Leslie, A. & Khader, S. (2019). Group 3 innate lymphoid cells mediate early protective immunity against tuberculosis. Nature 570, 528–532 doi:10.1038/s41586-019-1276-2.
Kloverpris, H. N., Kazer, S. W., Mjosberg, J., Mabuka, J. M., Wellmann, A., Ndhlovu, Z., Yadon, M. C., Nhamoyebonde, S., Muenchhoff, M., Simoni, Y., Andersson, F., Kuhn, W., Garrett, N., Burgers, W. A., Kamya, P., Pretorius, K., Dong, K., Moodley, A., Newell, E. W., Kasprowicz, V., Abdool Karim, S. S., Goulder, P., Shalek, A. K., Walker, B. D., Ndung'u, T., & Leslie, A. (2016). Innate Lymphoid Cells Are Depleted Irreversibly during Acute HIV-1 Infection in the Absence of Viral Suppression. Immunity, 44(2), 391-405. doi: 10.1093/infdis/jiw093.
Kloverpris, H. N., Leslie, A., & Goulder, P. (2015). Role of HLA Adaptation in HIV Evolution. Front Immunol, 6, 665. doi: 10.3389/fimmu.2015.00665.
Simoni, Y., Fehlings, M., Kloverpris, H. N., McGovern, N., Koo, S. L., Loh, C. Y., Lim, S., Kurioka, A., Fergusson, J. R., Tang, C. L., Kam, M. H., Dennis, K., Lim, T. K., Fui, A. C., Hoong, C. W., Chan, J. K., Curotto de Lafaille, M., Narayanan, S., Baig, S., Shabeer, M., Toh, S. E., Tan, H. K., Anicete, R., Tan, E. H., Takano, A., Klenerman, P., Leslie, A., Tan, D. S., Tan, I. B., Ginhoux, F., & Newell, E. W. (2016). Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency. Immunity. doi: 10.1016/j.immuni.2016.11.005.
Kloverpris, H. N., McGregor, R., McLaren, J. E., Ladell, K., Harndahl, M., Stryhn, A., Carlson, J. M., Koofhethile, C., Gerritsen, B., Kesmir, C., Chen, F., Riddell, L., Luzzi, G., Leslie, A., Walker, B. D., Ndung'u, T., & Buus, S. (2015). CD8+ TCR Bias and Immunodominance in HIV-1 Infection. 194(11), 5329-5345. doi: 10.4049/jimmunol.1400854.
Kloverpris, H. N., Cole, D. K., Fuller, A., Carlson, J., Beck, K., Schauenburg, A. J., Rizkallah, P. J., Buus, S., Sewell, A. K., & Goulder, P. (2015). A molecular switch in immunodominant HIV-1-specific CD8 T-cell epitopes shapes differential HLA-restricted escape. Retrovirology, 12, 20. doi: 10.1186/s12977-015-0149-5.