Wellcome Trust
site visit 2023

Documents

Programme

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Biosketches

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Abstracts

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Posters

Sensing of host Interferon-γby Mycobacterium tuberculosis

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SARS-CoV2 co-infection modulates immunometabolism of Mycobacterium tuberculosis-infected human macrophages

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HIV-1 Gag-protease driven replication capacity impacts cellular inflammation and glucose uptake of T cells.

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Beta variant infection combined with vaccination broadens neutralizing immunity against Omicron subvariants

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Quantitation of neutrophils and neutrophilassociated proteins in sputum to aid diagnosis of pulmonary TB

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Spatial localization of HIV infected macrophages in lymph nodes using multicolor Tissue FAX imaging

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Cross-sectional analysis reveals limited genetic diversity in genes that affect integration site targeting (Integrase and Capsid) in acute HIV-1 subtype C infection in South Africa

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HIV Escape and Resistance in the Brain: the HERB study pilot phase

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Research elected gut biopsies in people living with HIV show cross-compartment specific CD4+T-cell depletion in the upper small intestine

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Impact of HIV infection on Intestinal stem cell (ISC) proliferation and differentiation to determine their role during gut homeostasis in people living with HIV

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Type 3 ILCs in HIV-infected lymph nodes upregulate inflammatory pathways linked to tissue fibrosis

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Can vaccination stop SARS-CoV-2 prolonged infection in people with immunosuppression because of advanced HIV disease?

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The impact of HIV on the B-cell responses to SARS-CoV-2 in COVID-19-confirmed cases

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Effect of hybrid immunity on the neutralizing antibody response to emerging variants and in people living with HIV.

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Localized role for B-cells in the human TB lung.

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Clonal Dominance in TCR repertoire of Tissue- Resident memory in CD4+ and CD8+ T cells in Tuberculosis infected Individuals.

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Characterization of the naïve B-cell repertoire and antigen-specific B-cell precursors in a South African population to inform the development of germline-targeting HIV immunogens.

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Immuno-metabolic profiling of immune cells in Tuberculosis patients.

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Assessment of metabolic health of T-cells during TB infection by flow cytometry.

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Combination of traditional medicine product (SDK-2) with TNF-a synergistically reactivate latent HIV-1 subtype C in vitro.

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Lysophospholipids as mediators of lung inflammation and potential tuberculosis biomarkers.

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Discrepancy between Mtb-specific IFNγ and Mtb-specific IgG responses in HIV+ people with low CD4 counts.

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Cross-compartment specific changes of innate lymphoid cells in the gut of people living with HIV

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Physical characterization of latent tuberculosis lesions from post-mortem human lung tissue

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Role of the acid sphingomyelinase pathway in human Mycobacterium tuberculosis pathogenesis.

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A New Diagnostic Potential: Novel RNAscope and Immunohistochemistry provides insight in the detection of bacilli in human pulmonary TB tissue samples.

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Targeting spleen tyrosine kinase (SYK) for the control of TB-induced granulomatous pathology as a potential host-directed therapy.

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Characterizing inflammation in sub-clinical TB disease

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T cell immune responses to SARS-CoV-2 and common cold coronaviruses in South African and Zambian COVID-19 convalescent patients

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Immune gene spatial profiling of the HIV lymph node reservoir

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Targeting M. tuberculosis counteractome to potentiate BCG-induced trained immunity

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Potential LTBI biomarkers in ESAT-6 and CFP10 stimulated plasma

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Isolation and longitudinal characterization of the development of HIV broadly neutralizing antibodies.

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Longitudinal quantification of HIV proviral DNA and host APOBEC3G/-F mRNA expression in cellular subsets that are targeted by HIV-1.

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Identification and characterization of HIV viral reservoirs in palatine tonsils from children born with HIV.

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The inhibition of Mtb respiratory complexes modulate bioenergetics and metabolome.

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Prevalence of curable sexually transmitted infections in a population representative sample of young adults in South Africa.

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Association between prior tuberculosis disease and dysglycemia within an HIV-endemic, rural South African population.

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Delivery of school-based interventions to promoting adolescent health and well-being: Lessons from a multilevel HIV-prevention intervention through DREAMS in rural KwaZulu-Natal, South Africa

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Understanding the uptake of HIV care and prevention and the risk of acquiring and transmitting HIV amongst young women who sell sex in rural KwaZulu-Natal, South Africa

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Setting-up a clinical trials unit in rural South Africa: lessons learnt.

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What happened to my stock? Management and tracking of HIV selfscreening (HIV-SS) kit distribution in rural KwaZulu-Natal.

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Prevalence of Mycobacterium tuberculosis in sputum among adult clinic attendees compared with the surrounding community in rural South Africa: implications for finding the missing millions.

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Adaptation, acceptability and feasibility of a shortened Stepping Stones and Creating Futures intervention focused on HIV for young men in rural South Africa.

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An electronic Clinical Management System to support peer navigator- social mobilization of youth into decentralised HIV prevention services in rural KwaZulu Natal.

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Immunization for Children Living With HIV: A Scoping Review

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Correlates of physical activity among people living with and without HIV in rural Uganda.

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Common mental health disorders and HIV status among Adolescent Girls and Young Women in rural KwaZulu-Natal.

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Investigating the role of social capital and social cohesion in the creation of identity among young women who sell sex in rural KwaZulu-Natal.

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Undisclosed antiretroviral therapy use at primary health care clinics in rural KwaZulu-Natal South Africa: A DO-ART Trial Sub-study.

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Harnessing the social capital of rural communities for adolescent and youth biosocial HIV prevention: Exploring young people’s experiences and perceptions of a peer navigator intervention in KwaZulu-Natal, South Africa.

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Piloting and validating the linkage of routine ART and laboratory records in an HIV endemic setting.

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Viral load monitoring in public sector clinics in rural South Africa

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Population shifts in detectable HIV viral load in rural KwaZulu-Natal.

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Responsible drug advertising: An investigation into the marketing and promotion of Covid-19 preparations on social media in KwaZulu-Natal.

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“It felt like a weight was being taken off of my shoulders”: The impact of Lending a hand intervention in supporting migrant adolescents and young people, in KwaZulu-Natal, South Africa.

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Barriers and facilitators of tailored HIV prevention and community based sexual and reproductive health intervention: perspectives from the Isisekelo Sempilo Clinical Trial Process Evaluation in rural KZN, South Africa.

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Covid-19 and older people’s wellbeing in northern KwaZulu-Natal – the importance of relationships.

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Barriers, facilitators and opportunities for successful blood pressure control among people with hypertension in rural KwaZulu-Natal: Preparation for the IMPACT-BP Trial

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Examining Emerging Key Ethical Issues in the Planning, Review, and Implementation of Covid-19 Research in Africa, and the Preparedness and Responsiveness of Research Review Authorities.

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Infecting Minds: The Past, present, and future of Vaccine hesitancy in South Africa.

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Perceptions and experiences of young people adhering and not adhering to Highly Active Antiretroviral Therapy in sub-Saharan Africa: a scoping review.

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Agency among young people living with HIV in urban and rural KwaZulu-Natal.

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Progress toward discovering and testing whole blood transcriptomic correlates of protection in a human cohort.

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An evaluation of a combined psychological and parenting intervention for HIV-positive women depressed in the perinatal period, to enhance child development and reduce maternal depression: Study Protocol for the Insika Yomama Cluster Randomised Controlled Trial.

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Process evaluation: Understanding the implementation and adaptation of a peerled intervention to deliver biosocial HIV prevention for adolescents and youth in rural South Africa.

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The feasibility and acceptability of a combined therapy package for maternal depression and parenting adapted for telephonic delivery in a rural, low-income HIV-positive population in South Africa during Covid-19 – A Qualitative Investigation.

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Interrupted time series analysis to assess the impact of Covid-19 on M. tuberculosis transmission in uMkhanyakude district.

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Prevalence of curable sexually transmitted infections amongst female sex workers in rural KwaZulu-Natal.

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Features of symptomatic and asymptomatic prevalant TB in an HIV endemic rural South African district.

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Sexual and reproductive health needs of school-going children in the context of Covid-19 in rural KwaZulu-Natal, South Africa.

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Economic, Social, and Demographic impacts of drought on treatment adherence among people living with HIV in rural South Africa.

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Quantifying met and unmet health needs for HIV, hypertension and diabetes in rural KwaZulu-Natal, South Africa.

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Next generation HIV-1 sequencing reveals complex patterns of drug resistance and transmission in a rural African setting

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