Nigel Klein

Nigel Klein

Professor Nigel Klein is a member of AHRI faculty. He is professor and consultant in paediatric infectious diseases and immunology at Great Ormond Street Children’s Hospital, London, and the Institute of Child Health, University College London (UCL). He trained at UCL and has degrees in anatomy and in medicine. He went on to establish and lead the infectious diseases and microbiology unit at the Institute of Child Health until 2014 and established and led the department of infection at UCL for five years until 2008. He leads paediatric infection research at UCL. He has a particular interest in viral and bacterial infections of vulnerable young children, particularly understanding a child’s immune responses to infection and improving the care of children with HIV infection. He has a growing interest in the host microbiome and how it impacts on antibiotic treatment and the pathogenesis of inflammatory diseases. Nigel joined AHRI in 2016 as lead on paediatrics.

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Selected Recent Publications

Gates, L., Klein, N. J., Sebire, N. J., & Alber, D. G. (2021). Characterising Post-mortem Bacterial Translocation Under Clinical Conditions Using 16S rRNA Gene Sequencing in Two Animal Models. FRONTIERS IN MICROBIOLOGY, 12, ARTN 649312.

Anelone, A., Hancock, E., Klein, N., Kim, P., & Spurgeon, S. (2021). Control theory helps to resolve the measles paradox. Royal Society Open Science.

Payne, H., Lawrie, D., Nieuwoudt, M., Cotton, M., Gibb, D., Babiker, A., . . . Klein, N. (2020). Comparison of lymphocyte subset populations in children from South Africa, US and Europe. Frontiers in Pediatrics.

Hoare, R. L., Veys, P., Klein, N., Callard, R., & Standing, J. F. (2017). Predicting CD4 T-cell reconstitution following paediatric haematopoietic stem cell transplantation. Clin Pharmacol Ther. doi: 10.1002/cpt.621.

Rosser, E. C., Oleinika, K., Tonon, S., Doyle, R., Bosma, A., Carter, N. A.,Klein N. Mauri, C. (2014). Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production. Nat Med, 20 (11), 1334-1339. doi:10.1038/nm.3680.

Palma, P., Foster, C., Rojo, P., Zangari, P., Yates, A., Cotugno, N., Klein, N., Luzuriaga, K., Pahwa, S., Nastouli, E., Gibb, D. M., Borkowsky, W., Bernardi, S., Calvez, V., Manno, E., Mora, N., Compagnucci, A., Wahren, B., Munoz-Fernandez, M., De Rossi, A., Ananworanich, J., Pillay, D., Giaquinto, C., & Rossi, P. (2015). The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children. J Virus Erad, 1(3), 134-139.