Nigel Klein

Nigel Klein

Professor Nigel Klein is a member of AHRI Faculty. He is Professor and Consultant in Paediatric Infectious Diseases and Immunology at Great Ormond Street Children’s Hospital, London, and the Institute of Child Health, University College London (UCL). He trained at UCL and has degrees in Anatomy and in Medicine. He went on to establish and lead the Infectious Diseases and Microbiology Unit at the Institute of Child Health until 2014 and established and led the Department of Infection at UCL for five years until 2008. He leads Paediatric Infection Research at UCL. He has a particular interest in viral and bacterial infections of vulnerable young children, particularly understanding a child’s immune responses to infection and improving the care of children with HIV infection. He has a growing interest in the host microbiome and how it impacts on antibiotic treatment and the pathogenesis of inflammatory diseases. Nigel joined the Africa Centre for Population Health in 2016 as lead on Paediatrics.

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Selected Recent Publications

Doyle RM, Harris K, Kamiza S, Harjunmaa U, Ashorn U, Nkhoma M, Dewey KG, Maleta K, Ashorn P, Klein N (2017). Bacterial communities found in placental tissues are associated with severe chorioamnionitis and adverse birth outcomes. PLoS One. Jul 12;12(7):e0180167.

Prendergast AJ, Szubert AJ, Berejena C, Pimundu G, Pala P, Shonhai A, Musiime V, Bwakura-Dangarembizi M, Poulsom H, Hunter P, Musoke P, Kihembo M, Munderi P, Gibb DM, Spyer M, Walker AS, Klein N; ARROW Trial Team (2016). Baseline Inflammatory Biomarkers Identify Subgroups of HIV-Infected African Children With Differing Responses to Antiretroviral Therapy. J Infect Dis. Jul 15;214(2):226-36.

Hoare, R. L., Veys, P., Klein, N., Callard, R., & Standing, J. F. (2017). Predicting CD4 T-cell reconstitution following paediatric haematopoietic stem cell transplantation. Clin Pharmacol Ther. doi: 10.1002/cpt.621.

Rosser, E. C., Oleinika, K., Tonon, S., Doyle, R., Bosma, A., Carter, N. A.,Klein N. Mauri, C. (2014). Regulatory B cells are induced by gut microbiota-driven interleukin-1β and interleukin-6 production. Nat Med, 20 (11), 1334-1339. doi:10.1038/nm.3680.

Palma, P., Foster, C., Rojo, P., Zangari, P., Yates, A., Cotugno, N., Klein, N., Luzuriaga, K., Pahwa, S., Nastouli, E., Gibb, D. M., Borkowsky, W., Bernardi, S., Calvez, V., Manno, E., Mora, N., Compagnucci, A., Wahren, B., Munoz-Fernandez, M., De Rossi, A., Ananworanich, J., Pillay, D., Giaquinto, C., & Rossi, P. (2015). The EPIICAL project: an emerging global collaboration to investigate immunotherapeutic strategies in HIV-infected children. J Virus Erad, 1(3), 134-139.